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Newly Discovered Antimicrobial Peptide Scyampcin 44–63 from Scylla paramamosain Exhibits a Multitargeted Candidacidal Mechanism In Vitro and Is Effective in a Murine Model of Vaginal Candidiasis

Authors :
Ying Zhou
Xiangyu Meng
Fangyi Chen
Ming Xiong
Weibin Zhang
Ke-Jian Wang
Source :
Antimicrobial Agents and Chemotherapy.
Publication Year :
2023
Publisher :
American Society for Microbiology, 2023.

Abstract

The emergence of azole-resistant and biofilm-forming Candida spp. contributes to the constantly increasing incidence of vulvovaginal candidiasis. It is imperative to explore new antifungal drugs or potential substituents, such as antimicrobial peptides, to alleviate the serious crisis caused by resistant fungi.

Details

ISSN :
10986596 and 00664804
Database :
OpenAIRE
Journal :
Antimicrobial Agents and Chemotherapy
Accession number :
edsair.doi...........1f64e55676bbf4311c8797aa5a5854e0