EVALUATION OF MUTAGENIC ACTIVITY OF THE DRUG ON THE BASIS OF LACTIC AND PROPIONIC MICROORGANISMS IN VITRO

The mutagenic activity of the drug based on strains of lactic acid and propionic acid microorganisms showed that the studied drug and its metabolites did not induce reverse mutations from histidine auxotrophy to prototrophy in histidine-dependent Salmonella typhimurium TA98 and TA100 strains. The number of revertant colonies in the experiment and control differed significantly less than 2.0 times. The drug had a low MI of 1.0-1.1 for the TA98 strain and 0.96-1.07 for the TA100 strain. The data obtained indicate the safety of the drug based on lactic acid and propionic acid microorganisms, as well as the possibility of its further use in agriculture and veterinary medicine.