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Development of a Scalable Negishi Cross-Coupling Process for the Preparation of 2-Chloro-5-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-5-yl)aniline
- Source :
- Organic Process Research & Development. 25:434-441
- Publication Year :
- 2020
- Publisher :
- American Chemical Society (ACS), 2020.
-
Abstract
- A scalable synthesis of 2-chloro-5-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-5-yl)aniline (1), a key intermediate in the synthesis of an immuno-oncology asset, is described. A Negishi cross-coupling...
Details
- ISSN :
- 1520586X and 10836160
- Volume :
- 25
- Database :
- OpenAIRE
- Journal :
- Organic Process Research & Development
- Accession number :
- edsair.doi...........1f13d45db405b7d6237f0ec7178f1293
- Full Text :
- https://doi.org/10.1021/acs.oprd.0c00414