AB0245 Unmet Needs and Burden of Illness in Patients Currently Receiving Biologic Treatments for Rheumatoid Arthritis: A Comparison of Physician Perception of Remission and DAS28-Measured Remission in A Real World Study: Table 1

Background Biologics have greatly improved the management of rheumatoid arthritis (RA), demonstrating efficacy and safety in alleviating symptoms, inhibiting bone erosion, and preventing loss of function. 1 The current study hypothesis was that despite significant improvement in patient (pt) outcomes since the introduction of biologics, significant unmet need and burden of illness remains. Objectives The main objective was to test our primary hypothesis. Secondary objectives were to explore patterns of physician use of disease activity measures and compare degree of reported unmet need as ascertained by subjective physician assessment and objective disease activity measures. Methods Descriptive analyses of the following outcomes were performed using ADELPHI RA Disease Specific Program (DSP) data for US and EU5 pts who had been receiving biologic therapy ≥3 months: remission based on DAS28 ESR ( Results After ≥3 months on biologics (n=1299), 56% of pts were in remission based on physician judgement, while 31% were in remission based on DAS28 ESR ( P Conclusions There are significant unmet needs among RA pts on biologic treatment, regardless of line of therapy, suggesting the need for biologics with novel mechanisms of action. Remission based on physician judgement appeared to be over-reported as compared to remission indicated by disease activity measure DAS28. Clinical disease activity measures were not used consistently by physicians. Future study is warranted to explore whether under-utilization of disease activity measures is associated with the discrepancy between physician subjective judgement and clinical measurement. References Smolen JS, et al. Ann Rheum Dis. 2014;73(3):492–509. Disclosure of Interest S. Peterson Shareholder of: Janssen, Employee of: Janssen, E. Sullivan Employee of: Adelphi Real World, D. Kielar Shareholder of: Janssen, Employee of: Janssen, N. Li Employee of: Janssen