229-OR: Physical Fitness and Cardiovascular Risk Factors in Diabetes Subgroups

Physical inactivity promotes insulin resistance and increases the risk of diabetes and cardiovascular disease. Clustering based on simple clinical measures has been introduced for identifying diabetes subgroups with different risk of complications. However, little is known about physical fitness and cardiovascular risk factors in these clusters. We hypothesized that the insulin resistant diabetes (SIRD) cluster would associate with lower physical fitness and increased cardiovascular risk factors. Cycling spiroerogometry, physical activity questionnaire (Baecke index) and cardiovascular risk scores (Framingham Risk Scores (FRS) and triglycerides to high-density lipoproteins (TG:HDL) ratio) were analyzed in 746 participants with newly diagnosed diabetes of the German Diabetes Study (GDS). SIRD showed lower VO2max compared to the severe autoimmune diabetes (SAID), moderate age-related (MARD) and moderate obesity-related (MOD) clusters (all p In conclusion, SIRD and MARD showed lowest physical fitness and SIRD was least physically active and has the highest risk scores for diabetes-related cardiovascular diseases. Disclosure N. Saatmann: None. O. P. Zaharia: None. K. Strassburger: None. D. Pesta: None. V. Burkart: None. J. Szendroedi: None. M. Roden: Advisory Panel; Self; Allergan plc, Bristol-Myers Squibb Company, Novo Nordisk A/S, Research Support; Self; Boehringer Ingelheim International GmbH, Danone Nutricia, Sanofi-Aventis Deutschland GmbH.