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Common Impact of Chronic Kidney Disease and Brain Microhemorrhages on Cerebral Aβ Pathology in SHRSP
- Source :
- Brain Pathology. 27:169-180
- Publication Year :
- 2016
- Publisher :
- Wiley, 2016.
-
Abstract
- While chronic kidney disease seems to be an independent risk factor for cognitive decline, its impact on cerebral amyloid-β (Aβ) depositions, one hallmark of Alzheimer's Disease (AD) pathology, has not been investigated. Utilizing 80 male nontransgenic spontaneously hypertensive stroke prone rats (SHRSP) at various ages (12 to 44 weeks), tubulointerstitial renal damage, prevalence of cerebral microhemorrhages and Aβ accumulations were quantified. Using age-adjusted general linear models we investigated the main and interaction effects of renal damage and cerebral microhemorrhages on cerebral Aβ load. In addition, using post mortem human brain tissue of 16 stroke patients we examined the co-localization of perivascular Aβ deposits and small vessel wall damage. Statistical models revealed an age-independent main effect of tubulointerstitial kidney damage on brain Aβ accumulations, which was reinforced by the consecutive presence of cerebral microhemorrhages. Moreover, cerebral microhemorrhages independently predicted brain Aβ burden in SHRSP. In up to 69% of all human cases perivascular Aβ deposits were detected in the direct vicinity of small vessel wall damage. Our results support the associations between vascular pathology and Aβ deposition, and demonstrate a relationship between chronic kidney disease and cerebral Aβ pathology. Hence, our data suggest that prevention of chronic renal damage may reduce cerebral Aβ pathology.
- Subjects :
- 0301 basic medicine
Kidney
Pathology
medicine.medical_specialty
business.industry
General Neuroscience
Disease
Human brain
medicine.disease
Pathology and Forensic Medicine
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
medicine.anatomical_structure
medicine
Neurology (clinical)
Cerebral amyloid angiopathy
Alzheimer's disease
Cognitive decline
business
Stroke
030217 neurology & neurosurgery
Kidney disease
Subjects
Details
- ISSN :
- 10156305
- Volume :
- 27
- Database :
- OpenAIRE
- Journal :
- Brain Pathology
- Accession number :
- edsair.doi...........1ea31643f0c0129cc6bc0e9aff3115b9