Clinical study of imipenem/cilastatin sodium(IPM/CS. Tienam) in various acute infection in the field of oral and maxillofacial surgery

A clinical study of impenern/clastatin soditaum (IPM/CS Tienam®, ) was performed in various infections in the field of oral and maxillofacial surgery. Tienam was adminstered by intravenous drip infusion at a daily dose of lg (0.5g×2 times) to 40 patients with various infections.The subjects consisted of 34 maxillary ostitis, 2 phlegmon of the floor of the mouth, 2 parotitis, acute odontogenic maxillary sinusitis and 1 buccal abscess.The following results were obtained. The subjective evaluation was excellent in 23 cases, good in 21 cases and poor in 1 case.The scoring evaluation according to the scale proposed by Japanese Society of Oral Therapeutics and Pharmacology were excellent in 18 cases, good in 21 cases and poor in 1.The effective rate was 97.5% is both subjective and scoring evaluations. We examined bacteriological MIC of IPM/CS, TAPC, CCL, BAPC, AMPC, PIPC and OFLX.As a result, IPM/CS showed most favorable MIC data (90.3%) of all and there were no side effects.The laboratory values shifted favorably with time elapsed.The results indicated the usefulness of IPM/CS in the treatment of various infections in the field of oral surgery.