Back to Search
Start Over
A pilot study of 13N-ammonia cardiac PET imaging to assess subacute cardiotoxicity following adjuvant intensity-modulated radiotherapy for locally advanced breast cancer
- Source :
- Clinical Imaging. 68:283-290
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Objective (1) Assess the feasibility of 13 N-ammonia cardiac PET (13 N-ammonia-PET) imaging in radiotherapy (RT) treatment position in locally-advanced breast cancer (LABC) patients. (2) Correlate pre−/post-RT changes in myocardial flow reserve (MFR) with the corresponding radiation heart dose. Methods Ten left-sided LABC patients undergoing Volumetric Modulated-Arc-Therapy (VMAT) to chest wall and regional lymph nodes underwent a rest/stress 13 N-ammonia-PET at baseline and (median) 13 months post-RT. Changes in cardiac functions and coronary artery Ca2+ scoring between baseline and follow-up were correlated with average RT dose to the myocardium,3 coronary territories, and 17 myocardial segments. Results Eight (of 10) patients successfully completed the study. The average rest (stress) global MBF (ml.g-1.min-1) for baseline (follow-up) were 0.83 ± 0.25 (2.4 ± 0.79) and 0.92 ± 0.30 (2.76 ± 0.71), respectively. Differences in MBF, heart rate, blood pressure, and rate-pressure product (RPP) between baseline and follow-up were insignificant (P > 0.1).Strong (R = 0.79; P 50) for all patients in both studies. Conclusion The feasibility of 13 N-ammonia-PET imaging in treatment position of LABC patients was demonstrated. MFR at 1-year post-irradiation of the heart decreased in 50% of the patients. MFR may be a potential index for early detection of cardiotoxicity in BC patients receiving RT to the chest wall.
- Subjects :
- Cardiotoxicity
business.industry
medicine.medical_treatment
medicine.disease
030218 nuclear medicine & medical imaging
Radiation therapy
03 medical and health sciences
0302 clinical medicine
Blood pressure
Breast cancer
medicine.anatomical_structure
Cardiac PET
030220 oncology & carcinogenesis
Heart rate
medicine
Radiology, Nuclear Medicine and imaging
Lymph
business
Nuclear medicine
Artery
Subjects
Details
- ISSN :
- 08997071
- Volume :
- 68
- Database :
- OpenAIRE
- Journal :
- Clinical Imaging
- Accession number :
- edsair.doi...........1e8c687489f68ffd1d86fddcf5802096