Association of vitamin D receptor gene with anthropometric measures in Komi ethnic group

The relationship between the vitamin D receptor gene (VDR) variants with serum 25-OHD3 concentration, body height (BH), body weight (BW), and body composition were examined in the Komi ethnic group. The FF-genotype was associated with higher BW (p = 0.002) and lower bone mass (BM, p = 0.06) in comparison to the Ff-genotype carriers. The BB-genotype carriers were characterized by lower BL compared to those with Bb-genotype (p = 0.037); BM was lower among those having bb rather than Bb variants (p = 0.025). No differences in the 25-OHD3 content were revealed. The results are consistent with the data obtained for populations from North-Western Europe and opposite to those reported for tropical and subtropical Caucasians, as well as for non-Caucasians groups.