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Hemoglobin Hasharon [α2 47 (CD5) Asp→ His β2]Linked to α-Thalassemia in Northern Italian Carriers
- Source :
- Acta Haematologica. 63:305-311
- Publication Year :
- 1980
- Publisher :
- S. Karger AG, 1980.
-
Abstract
- This report is concerned with the evaluation of hematological parameters and of both relative (%) and absolute (mean pg/cell) quantities of the abnormal Hemoglobin (Hb) Hasharon in 53 heterozygous carriers and 7 double heterozygotes for Hb Hasharon and beta-thalassemia from 43 apparently unrelated families living in the province of Rovigo (northern Italy). Biosynthetic studies are also reported. The data strongly suggest the presence of an alpha-thalassemia-2 determinant closely linked to the alpha Hasharon-chain locus. Selective advantage of heterozygotes carrying such alpha-haplotype would explain the relatively high frequency of Hb Hasharon (0.23%) in northeastern Italy, a past-endemic malaria region. The interaction between Hb Hasharon and beta-thalassemia results in preferential decrease of the abnormal Hb level.
Details
- ISSN :
- 14219662 and 00015792
- Volume :
- 63
- Database :
- OpenAIRE
- Journal :
- Acta Haematologica
- Accession number :
- edsair.doi...........1e52f8a8aab6088ec61caa2e2ed993a7