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A Retrospective- Prospective Study for the Efficacy and Safety of Entecavir in a Cohort of West Asian with Chronic HBV Infection
- Source :
- Suez Canal University Medical Journal. 19:201-212
- Publication Year :
- 2016
- Publisher :
- Egypts Presidential Specialized Council for Education and Scientific Research, 2016.
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Abstract
- Aim: To assess the long-term efficacy and safety of Entecavir in the treatment of CHB. Patients and Methods: This study included 70 CHB consecutive patients on Entecavir for at least 36 months retrospectively, followed prospectively for 18 months. Results: twenty-three (32.8) were HBeAg +ve, 47.1% naive, 22 (31.4%) females, with a mean age of 42.9±13, 14 (20%) cirrhotic and 1 (1.4%) decompensated. There were no significant differences in the pre-treatment HBV-DNA level among HBeAg (+ve) and HBeAg-ve group, with a mean± SD log 10 of 7.9±5.4 and 7.4±5.0 respectively. (P= 0.237). There was a significant viral load reduction after 6 months Entecavir therapy that was more in the HBeAg –ve compared to HBeAg +ve group. In HBeAg +ve, 19 (82.61%) had HBV-DNA suppression after a median of 7 months, compared to 100% in HBeAg –ve with a median of 5 months (P
Details
- ISSN :
- 20902581
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Suez Canal University Medical Journal
- Accession number :
- edsair.doi...........1e0b2ec6c83c6504aa8ed0ca708a8d83