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Endoplasmic Reticulum–Plasma Membrane Junctions as Sites of Depolarization-Induced Ca2+ Signaling in Excitable Cells
- Source :
- Annual Review of Physiology. 85:217-243
- Publication Year :
- 2023
- Publisher :
- Annual Reviews, 2023.
-
Abstract
- Membrane contact sites between endoplasmic reticulum (ER) and plasma membrane (PM), or ER-PM junctions, are found in all eukaryotic cells. In excitable cells they play unique roles in organizing diverse forms of Ca2+ signaling as triggered by membrane depolarization. ER-PM junctions underlie crucial physiological processes such as excitation-contraction coupling, smooth muscle contraction and relaxation, and various forms of activity-dependent signaling and plasticity in neurons. In many cases the structure and molecular composition of ER-PM junctions in excitable cells comprise important regulatory feedback loops linking depolarization-induced Ca2+ signaling at these sites to the regulation of membrane potential. Here, we describe recent findings on physiological roles and molecular composition of native ER-PM junctions in excitable cells. We focus on recent studies that provide new insights into canonical forms of depolarization-induced Ca2+ signaling occurring at junctional triads and dyads of striated muscle, as well as the diversity of ER-PM junctions in these cells and in smooth muscle and neurons.
- Subjects :
- Physiology
Subjects
Details
- ISSN :
- 15451585 and 00664278
- Volume :
- 85
- Database :
- OpenAIRE
- Journal :
- Annual Review of Physiology
- Accession number :
- edsair.doi...........1de058f201f455421928338502ad9e24