531 METFORMIN SUPPRESSES MYELOID-DERIVED SUPPRESSOR CELLS AND M2 MACROPHAGES THROUGH INHIBITION OF THE MEVALONATE PATHWAY BY AMPK-ACTIVATION AND MTOR INHIBITION IN THE MICROENVIRONMENT OF COLITIC CANCER

Authors :: Jae Jun Park
Won Ho Kim
J.K. Kang
Jae Hee Cheon
Tae Il Kim
Soo Jung Park
Source :: Gastroenterology. 160:S-108
Publication Year :: 2021
Publisher :: Elsevier BV, 2021.

Subjects :: Hepatology
Chemistry
Gastroenterology
Cancer research
Myeloid-derived Suppressor Cell
medicine
AMPK
Colitic cancer
Mevalonate pathway
PI3K/AKT/mTOR pathway
Metformin
medicine.drug

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