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Rapid and label-free sensing of intermolecular interactions using compact optical diffusion sensor
- Source :
- International Journal of Heat and Mass Transfer. 133:73-79
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Diffusion sensors for nano-sized materials dispersed in a solution are promising tools for investigating intermolecular interactions, which is an important task in a wide range of industrial and biomedical fields, such as the development of therapeutic products and diagnostic tools. For the development of the sensor applicable to point-of-care testing, an optofluidic sensor was proposed. The proposed sensor realizes a simple measurement in a short time using microscale manipulation by interferometrically-induced dielectrophoresis and optical detection. In this paper, the applicability of the proposed sensor to distinguish nanoscale differences in size was confirmed by measurements on a solution containing size-certified plain nano-beads (51 nm, 100 nm, 203 nm, 216 nm and 240 nm) with evaluating the uncertainties of the proposed sensor. Furthermore, measurements using 200-nm beads coated with functional groups (NH2 and biotin) and proteins (streptavidin and bovine serum albumin) demonstrated the applicability to the investigation of intermolecular interactions.
- Subjects :
- Fluid Flow and Transfer Processes
Streptavidin
Materials science
Mechanical Engineering
Intermolecular force
Nanotechnology
02 engineering and technology
Dielectrophoresis
021001 nanoscience & nanotechnology
Condensed Matter Physics
Diagnostic tools
01 natural sciences
010305 fluids & plasmas
chemistry.chemical_compound
chemistry
0103 physical sciences
Diffusion (business)
0210 nano-technology
Nanoscopic scale
Microscale chemistry
Label free
Subjects
Details
- ISSN :
- 00179310
- Volume :
- 133
- Database :
- OpenAIRE
- Journal :
- International Journal of Heat and Mass Transfer
- Accession number :
- edsair.doi...........1d5c65397fe37e3800abb148a9f79f15