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A phase I study of ARRY-520 in solid tumors

Authors :
A. M. Ptaszynski
Edward A. Sausville
N. B. Pandya
Martin J. Edelman
Burgess B. Freeman
Patricia LoRusso
M. M. Houlehan
Heidi Simmons
Priscila H. Goncalves
J. S. Stallings
Source :
Journal of Clinical Oncology. 28:2570-2570
Publication Year :
2010
Publisher :
American Society of Clinical Oncology (ASCO), 2010.

Abstract

2570 Background: Antimitotic therapy stabilizes microtubule polymers and inhibits tubulin polymerization, but is nonselective and causes neurotoxicity. Kinesin Spindle Protein (KSP) is responsible ...

Subjects

Subjects :
chemistry.chemical_classification
Cancer Research
business.industry
Neurotoxicity
macromolecular substances
Polymer
medicine.disease
Phase i study
Oncology
chemistry
Microtubule
medicine
Biophysics
Tubulin polymerization
Kinesin
business

Details

ISSN :
15277755 and 0732183X
Volume :
28
Database :
OpenAIRE
Journal :
Journal of Clinical Oncology
Accession number :
edsair.doi...........1d58058d93e6e96974f0904613483890
Full Text :
https://doi.org/10.1200/jco.2010.28.15_suppl.2570
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