A higher rate of adverse pregnancy outcome in HBsAg-positive pregnant woman

Objective The aim of this study was to study the relationship between adverse pregnant outcomes(APO) with chronic hepatitis B virus (HBV) infection in pregnant women. Method From 2017 to 2019, we studied HBsAg (+) pregnant women and HBsAg (-) who gave birth at our hospital in Guangzhou City, China. We compared of the outcomes of pregnant women with HBsAg(+) or HBsAg(-). Further, among HBsAg(+) pregnant women, We compared of the outcomes of pregnant women with HBeAg(+) group or HBeAg(-) group, HBV DNA above 2×10e5IU/mL group or HBV DNA below 2×10e5IU/mL) group, respectively. Finally, multivariate logistic regression analysis was used to evaluate the independent association between HBV infection and the risk of developing APO. Result First, Our research Indicates that the rates of gestational diabetes mellitus (GDM), intrahepatic cholestasis of pregnancy (ICP), premature rupture of membrane (PROM), Fetal distress (FD), Oligohydramnios, Premature delivery (PD), Low birth weight (LBW), Meconium contamination (MC), Neonatal hyperbilirubinemia(NH) in HBsAg(+) group were higher than those in HBsAg(-) group (P5 IU/mL were higher than those in HBV DNA below 2×10e5 IU/mL group (P