Back to Search
Start Over
Inflammatory Bowel Disease
- Source :
- Gastroenterology Clinics of North America. 47:755-772
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract, of which ulcerative colitis and Crohn's disease are the 2 most prevailing entities. Very early onset IBD (VEO-IBD) children diagnosed with IBD under age 6 years. Although the etiology of IBD is mostly unknown, it involves a complex interaction among host genetics, microbiota, environmental factors, and aberrant immune responses. Advances in the understanding of the genetic contribution, which appears to be much more significant in younger children, gives us a useful insight into the pathogenesis and potential future therapeutic targets in IBD.
- Subjects :
- 0301 basic medicine
Gastrointestinal tract
business.industry
medicine.medical_treatment
Gastroenterology
Disease
medicine.disease
digestive system
Inflammatory bowel disease
Ulcerative colitis
digestive system diseases
Targeted therapy
Pathogenesis
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
Immune system
Immunology
medicine
Etiology
030211 gastroenterology & hepatology
business
Subjects
Details
- ISSN :
- 08898553
- Volume :
- 47
- Database :
- OpenAIRE
- Journal :
- Gastroenterology Clinics of North America
- Accession number :
- edsair.doi...........1cc055f79b1ab49ca57e3ff468f064b3