A NewGγ Chain Variant: Hb F-Bron [γ20(B2)Val→Ala]

Authors :: Michel Becchi
Philippe Lacan
Nicole Couprie
Martine Aubry
Nelly Burnichon
Isabelle Zanella-Cléon
Alain Francina
Source :: Hemoglobin. 29:301-305
Publication Year :: 2005
Publisher :: Informa UK Limited, 2005.
Abstract: A new G(gamma) hemoglobin (Hb) variant, Hb F-Bron [gamma20(B2)Val-->Ala] on the first exon of the G(gamma)-globin gene is described. The variant was characterized by DNA sequencing and mass spectrometry (MS). Hematological abnormalities included hypochromia and microcytosis and were probably caused by an interaction with an alpha-thalassemia (thal) (3.7 kb) deletion in the heterozygous state.