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SAT0243 Endothelial dysfunction reflected by high S-ICAM-1 and VWF levels accelerates coronary atherosclerosis in systemic lupus erythematosus patients
- Source :
- Annals of the Rheumatic Diseases. 71:554.1-554
- Publication Year :
- 2013
- Publisher :
- BMJ, 2013.
-
Abstract
- Background Conventional risk factors of coronary artery disease fail to explain accelerated atherosclerosis in systemic lupus erythematosus (SLE) patients. Clinical and experimental studies shows that soluble intercellular adhesion molecule 1 (sICAM-1) and von Willebrand factor (vWF) levels reflect endothelial damage or dysfunction. Objectives This study was conducted to determine the possible influence of endothelial pathology assessed by sICAM-1 and vWF levels on coronary artery calcifications in SLE patients. Methods In 60 SLE patients in stable clinical conditions, without a prior history of coronary artery disease, MultiDetector Computed Tomography (MDCT)-based coronary calcium scoring was performed. Laboratory evaluation included serum concentrations of sICAM-1, vWF, C-reactive protein (CRP) and antinuclear antibodies (ANA) titers. Results MDCT revealed coronary calcifications in 15 (25%) patients. Calcium scores ranged from 0.3 to 843.2 (median 31,7). No association was found between these scores and conventional coronary artery disease risk factors (obesity, hypertension, tobacco use, hyperlipidaemia, diabetes) nor CRP levels. On the contrary, as compared to patients with calcium score =0, in those with coronary calcifications higher concentrations of sICAM-1 (382.2±328.2 vs. 267.1±62.7, p=0.01), vWF (188.5±87.6 vs. 149.2±52.2, p=0.025) and higher ANA titers (8320±4521 vs. 4668±2717, p=0.03) were found. Conclusions Conventional risk factors of coronary artery disease as well as markers of an ongoing inflammation do not show significant association with coronary artery calcifications in SLE patients. Calcified atherosclerotic plaques were observed mainly in patients with elevated levels of sICAM-1, vWF or high ANA titers. The sICAM-1 and vWF levels may serve as a possible risk marker of coronary calcifications and may have a prognostic importance. Disclosure of Interest None Declared
- Subjects :
- ICAM-1
medicine.medical_specialty
Anti-nuclear antibody
biology
business.industry
Immunology
medicine.disease
General Biochemistry, Genetics and Molecular Biology
Coronary artery disease
medicine.anatomical_structure
Rheumatology
Von Willebrand factor
Internal medicine
Diabetes mellitus
medicine
Cardiology
biology.protein
Immunology and Allergy
Endothelial dysfunction
business
Coronary atherosclerosis
Artery
Subjects
Details
- ISSN :
- 14682060 and 00034967
- Volume :
- 71
- Database :
- OpenAIRE
- Journal :
- Annals of the Rheumatic Diseases
- Accession number :
- edsair.doi...........1bb6bbec804807c34bef8a4583e8787c