Reactivation of Organophosphorus — Inhibited Human Erythrocyte-Acetylcholinesterase by Oximes in vitro

Until now the efficacy of new antidotes against organophosphorus poisoning has been primarily evaluated in animal models. However, the transmission of these results to humans is hampered by species differences. Besides atropine, oximes are considered as main antidotes. The most important effect of these compounds is the reactivation of inhibited acetylcholinesterase (AChE). The reactivating potency of oximes can be investigated with human material in vitro and was evaluated in the present study with human erythrocyte AChE after inhibition by different nerve agents and pesticides.