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Key molecular mechanisms associated with cell malignant transformation in acute myeloid leukemia
- Source :
- Molecular Biology. 50:344-352
- Publication Year :
- 2016
- Publisher :
- Pleiades Publishing Ltd, 2016.
-
Abstract
- Cancer, along with cardiovascular disorders, is one of the most important problems of healthcare. Pathologies of the hematopoietic system are the most prevalent in patients under 30 years of age, including acute myeloid leukemia (AML), which is widespread and difficult to treat. The review considers the mechanisms that play a significant role in AML cell malignant transformation and shows the contributions of certain genes to both remission and resistance of AML cells to various treatments.
- Subjects :
- 0301 basic medicine
DNA repair
Cell
Biophysics
Myeloid leukemia
Cancer
Biology
medicine.disease
Human genetics
Malignant transformation
03 medical and health sciences
Haematopoiesis
030104 developmental biology
0302 clinical medicine
medicine.anatomical_structure
Structural Biology
hemic and lymphatic diseases
030220 oncology & carcinogenesis
Immunology
Cancer research
medicine
Signal transduction
neoplasms
Subjects
Details
- ISSN :
- 16083245 and 00268933
- Volume :
- 50
- Database :
- OpenAIRE
- Journal :
- Molecular Biology
- Accession number :
- edsair.doi...........1b853b53d4a73e72b062fd1439d8b001