Randomized placebo-controlled trial of testosterone replacement in men with mild Leydig cell insufficiency following cytotoxic chemotherapy

OBJECTIVE Testosterone deficiency is associated with significant morbidity, and androgen replacement in overt hypogonadism is clearly beneficial. However, there are few data concerning the response to therapy in young men with mild testosterone deficiency. DESIGN AND PATIENTS We have identified a cohort of 35 men, mean age 40·9 years, with mild Leydig cell dysfunction, defined by a raised LH level (LH ≥ 8 IU/l) and a testosterone level in the lower half of the normal range or frankly subnormal (testosterone