Synthesis of (S)-3-hydroxytetrahydropyran from l -glutamic acid

A concise synthesis of (S)-3-hydroxytetrahydropyran from natural l -glutamic acid has been developed. The intramolecular etherification starting from 1,5-diol was promoted by trifluoromethanesulfonic anhydride. The clinnamates of the alcohols were prepared for accurately determining the optical purity by HPLC method.