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Molecular aspects of adrenergic modulation of cardiac L-type Ca channels
- Source :
- Cardiovascular Research. 65:28-39
- Publication Year :
- 2005
- Publisher :
- Oxford University Press (OUP), 2005.
-
Abstract
- L-type Ca(2+) channels are predominantly regulated by beta-adrenergic stimulation, enhancing L-type Ca(2+) current by increasing the mean channel open time and/or the opening probability of functional Ca(2+) channels. Stimulation of beta-adrenergic receptors (ARs) results in an increased cyclic adenosine monophosphate (cAMP) production by adenylate cyclase (AC) and consequently activation of protein kinase (PK) A and phosphorylation of L-type Ca(2+) channels by this enzyme. Beta(1)-Adrenergic receptors couple exclusively to the G protein Gs, producing a widespread increase in cAMP levels in the cell, whereas beta(2)-adrenergic receptors couple to both Gs and Gi, producing a more localized activation of L-type Ca(2+) channels. Other signaling intermediates (protein kinase C, protein kinase G or protein tyrosine kinase (PTK)) either have negative effects on L-type Ca(2+) current, or they interact with the stimulatory effect of the protein kinase A pathway.
- Subjects :
- Physiology
Akt/PKB signaling pathway
Cyclin-dependent kinase 2
Biology
Mitogen-activated protein kinase kinase
Molecular biology
chemistry.chemical_compound
chemistry
Physiology (medical)
Ca2+/calmodulin-dependent protein kinase
biology.protein
Cyclic adenosine monophosphate
Cardiology and Cardiovascular Medicine
Protein kinase A
cGMP-dependent protein kinase
G protein-coupled receptor
Subjects
Details
- ISSN :
- 00086363
- Volume :
- 65
- Database :
- OpenAIRE
- Journal :
- Cardiovascular Research
- Accession number :
- edsair.doi...........19dd667f1acfead7cc5b5a8399d3e987