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Corrosion of intracellular granules and cell death
- Source :
- Proceedings of the Royal Society of London. Series B. Biological Sciences. 234:463-476
- Publication Year :
- 1988
- Publisher :
- The Royal Society, 1988.
-
Abstract
- The snail Helix aspersa has large numbers of calcium cells in its hepatopancreas which contain membrane-bound intracellular granules of CaMgP 2 O 7 . These inorganic deposits are the sites of accumulation of a wide variety of cations and act as a detoxification mechanism that traps a number of dietary metals once they have entered the animal. This study concentrates on the mechanism of incorporation of manganese ions into these deposits by using electron microscopy, ultra-low-angle X-ray scattering and extended X-ray absorption spectroscopy. The results show that manganese ions cause a localized corrosion of these intracellular granules with a consequent release of calcium ions. This release appears to overwhelm the calcium-regulatory mechanisms of these cells and leads to their death and subsequent shedding into the lumen of the alimentary tract. The concept of intracellular corrosion is a novel interpretation of a previously unsuspected biochemical lesion.
- Subjects :
- Programmed cell death
biology
General Engineering
chemistry.chemical_element
Manganese
Snail
Calcium
biology.organism_classification
Corrosion
law.invention
Crystallography
chemistry
law
biology.animal
Biophysics
General Earth and Planetary Sciences
Hepatopancreas
Electron microscope
Intracellular
General Environmental Science
Subjects
Details
- ISSN :
- 20539193 and 00804649
- Volume :
- 234
- Database :
- OpenAIRE
- Journal :
- Proceedings of the Royal Society of London. Series B. Biological Sciences
- Accession number :
- edsair.doi...........18cc84d7b60b0b1f44b182a721ac9afc