Preliminary structural analysis of the mutations selected by non-nucleoside inhibitors of HIV-1 reverse transcriptase

The crystal structure of HIV reverse transcriptase complexed with nevirapine showed that most of the mutations that confer resistance to non-nucleoside inhibitors of RT are clustered around the nevirapine binding pocket. Establishment of favorable interactions with conserved residues in this pocket is essential for the design of second generation RT inhibitors.