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Artificially produced gametes in mice, humans and other species
- Source :
- Reproduction, Fertility and Development. 33:91
- Publication Year :
- 2021
- Publisher :
- CSIRO Publishing, 2021.
-
Abstract
- The production of gametes from pluripotent stem cells in culture, also known as invitro gametogenesis, will make an important contribution to reproductive biology and regenerative medicine, both as a unique tool for understanding germ cell development and as an alternative source of gametes for reproduction. Invitro gametogenesis was developed using mouse pluripotent stem cells but is increasingly being applied in other mammalian species, including humans. In principle, the entire process of germ cell development is nearly reconstitutable in culture using mouse pluripotent stem cells, although the fidelity of differentiation processes and the quality of resultant gametes remain to be refined. The methodology in the mouse system is only partially applicable to other species, and thus it must be optimised for each species. In this review, we update the current status of invitro gametogenesis in mice, humans and other animals, and discuss challenges for further development of this technology.
- Subjects :
- 0303 health sciences
media_common.quotation_subject
Reproductive technology
Biology
Regenerative medicine
Cell biology
03 medical and health sciences
0302 clinical medicine
Endocrinology
medicine.anatomical_structure
Reproductive Medicine
Genetics
medicine
Animal Science and Zoology
Reproduction
Induced pluripotent stem cell
Molecular Biology
030217 neurology & neurosurgery
Germ cell
Gametogenesis
030304 developmental biology
Developmental Biology
Biotechnology
media_common
Subjects
Details
- ISSN :
- 10313613
- Volume :
- 33
- Database :
- OpenAIRE
- Journal :
- Reproduction, Fertility and Development
- Accession number :
- edsair.doi...........18354280a733351c048eb6a144cc925f