ChemInform Abstract: tert-Butanesulfinylthioether Ligands: Synthesis and Application in Palladium-Catalyzed Asymmetric Allylic Alkylation

A class of novel chiral SO-S-type bidentate ligands based on the tert-butylsulfinyl moiety as the sole chiral source were designed and synthesized through a simple and efficient pathway. These ligands are effective catalyst precursors for the palladium-catalyzed allylic alkylation of 1,3-diphenyl-2-propenyl acetate and moderate to good stereoselectivities (up to 84% ee) were obtained. (C) 2011 Elsevier Ltd. All rights reserved.