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Asymmetric bioreduction ofp-haloacetophenones byMucor
- Source :
- Biocatalysis and Biotransformation. 31:323-328
- Publication Year :
- 2013
- Publisher :
- Informa UK Limited, 2013.
-
Abstract
- A number of p-haloacetophenones were asymmetrically bioreduced to their corresponding (S)-alcohols by Mucor sp. CG10 with good conversion and excellent enantioselectivity. The results showed that the electronic effects of the halogen substituent (X-group) affected the conversion of the substrates and the enantioselectivity of the reaction. The trend observed was as the X-group at the para-position became more electron donating from F, to Cl, Br and I, the conversion of substrates decreased, while the enantioselectivity increased.
Details
- ISSN :
- 10292446 and 10242422
- Volume :
- 31
- Database :
- OpenAIRE
- Journal :
- Biocatalysis and Biotransformation
- Accession number :
- edsair.doi...........172e44a1550d3227f87124792f4008d0
- Full Text :
- https://doi.org/10.3109/10242422.2013.858710