Back to Search Start Over

Asymmetric bioreduction ofp-haloacetophenones byMucor

Authors :
Fang Shen
Zuohui Zhang
Meifang Zhuo
Xiongmin Liu
Li Ma
Source :
Biocatalysis and Biotransformation. 31:323-328
Publication Year :
2013
Publisher :
Informa UK Limited, 2013.

Abstract

A number of p-haloacetophenones were asymmetrically bioreduced to their corresponding (S)-alcohols by Mucor sp. CG10 with good conversion and excellent enantioselectivity. The results showed that the electronic effects of the halogen substituent (X-group) affected the conversion of the substrates and the enantioselectivity of the reaction. The trend observed was as the X-group at the para-position became more electron donating from F, to Cl, Br and I, the conversion of substrates decreased, while the enantioselectivity increased.

Details

ISSN :
10292446 and 10242422
Volume :
31
Database :
OpenAIRE
Journal :
Biocatalysis and Biotransformation
Accession number :
edsair.doi...........172e44a1550d3227f87124792f4008d0
Full Text :
https://doi.org/10.3109/10242422.2013.858710