A Novel Dimeric Podophyllotoxin-Type Lignan and a New Withanolide from Withania coagulans

A novel dimeric lignan, bispicropodophyllin glucoside (1) and a highly oxygenated new withanolide, coagulin S (2) were isolated from the ethanolic extract of Withania coagulans. The structures were established on the basis of the spectroscopic data and have been identified as (5S*,5aR*,8aR*,9S*,15S*,15aS*,18aS*,19S*)-9,19-di-β-D-glucopyranosyl-5,8a,9,15,15a,18,18a,19-octahydro-5,15-bis(3,4,5-trimethoxyphenyl)bis([1,3]dioxolo[4′,5′:6,7]naphtho)[2,3-c:2,3-h][1,6]dioxecin-6,16(5aH,8H)-dione (1) and (20S*,22R*)-5α,6β,14α,15α,17β,20,27-heptahydroxy-1-oxowith-24-enolide (2), respectively.