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Pathological findings and prostate-specific antigen outcomes after laparoscopic radical prostatectomy for high-risk prostate cancer
- Source :
- BJU International. 106:86-90
- Publication Year :
- 2009
- Publisher :
- Wiley, 2009.
-
Abstract
- Study Type – Therapy (case series) Level of Evidence 4 OBJECTIVE To review the biochemical recurrence-free survival (RFS) rates of laparoscopic radical prostatectomy (LRP) in patients with a high risk of disease progression as defined by preoperative criteria of D’Amico et al. PATIENTS AND METHODS Between October 2000 and May 2008, 110 patients had extraperitoneal LRP and bilateral pelvic lymph node sampling for high-risk prostate cancer in our department. High-risk prostate cancer was defined as a prostate-specific antigen (PSA) level of >20 ng/mL, and/or a biopsy Gleason score ≥8, and/or a clinical stage of T2c–T4 stage. The median follow-up was 37.6 months. Risk factors for time to biochemical recurrence were tested using log-rank survivorship analysis and Cox proportional hazards regression. RESULTS Prostate cancer was organ-confined in 36% of patients; the Overall RFS was 79.4% and 69.8% at 1 and 3 years, respectively. The 3-year RFS rates for organ-confined cancer vs extracapsular extension were 100% and 54.3%, respectively (P
- Subjects :
- Biochemical recurrence
medicine.medical_specialty
Laparoscopic radical prostatectomy
business.industry
Urology
medicine.medical_treatment
030232 urology & nephrology
Cancer
medicine.disease
3. Good health
03 medical and health sciences
Prostate-specific antigen
Prostate cancer
0302 clinical medicine
PSA Failure
030220 oncology & carcinogenesis
medicine
Stage (cooking)
Risk factor
business
Subjects
Details
- ISSN :
- 1464410X and 14644096
- Volume :
- 106
- Database :
- OpenAIRE
- Journal :
- BJU International
- Accession number :
- edsair.doi...........16e7d35ca97d610aac8c602132ce7531