Synthèses et activités psychotropes de 3,4-diarylpipéridines. Corrélation structure-activité et recherche d'une activité antihypertensive

Interesting psychotropic properties (psychostimulant, anti-depressant) were shown for a series of 3,4-diarylpiperidines. Optimization of these properties was obtained by Topliss method for determining the structure-activity relationship. Anti-depressant activity with little psychostimulant effect was observed in Mice and Rats with the trans 4-(4-trifluoromethylphenyl)-3-phenyl piperidine. Antihypertensive activity was not found among dopamine chained piperidines. Synthesis, relative configuration and conformation, pharmacologic study of 3,4-diarylpiperidines are described.