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Improved Synthesis of Vitamin K1

Authors :
Zhi-Min Zong
Ya-Fei Ji
Lin-Tao He
Li Xu
Guang-Zhong Tu
Xian-Yong Wei
Source :
ChemInform. 34
Publication Year :
2003
Publisher :
Wiley, 2003.

Abstract

With (E/Z)-isomeric phytyl halides as side-chain materials, vitamin K 1 is synthesized via a Diels–Alder reaction to activate the free bridgehead hydrogen of 3 for the alkylation and a retro-Diels–Alder reaction to eliminate cyclopentadiene from 2 in a high yield, in which the configuration of the double bond in the phytyl side-chain is retained.

Subjects

Subjects :
chemistry.chemical_classification
Vitamin
Cyclopentadiene
Double bond
Hydrogen
Halide
chemistry.chemical_element
General Medicine
Vitamin k
Alkylation
Medicinal chemistry
chemistry.chemical_compound
chemistry
Yield (chemistry)

Details

ISSN :
15222667 and 09317597
Volume :
34
Database :
OpenAIRE
Journal :
ChemInform
Accession number :
edsair.doi...........15cf6bbab9d36f67fffbf0c91585418a

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