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Green Synthesis and Characterization of Biologically Active Silver Nanoparticles Using Perilla frutescens Leaf Extract
- Source :
- Journal of Cluster Science. 28:81-90
- Publication Year :
- 2016
- Publisher :
- Springer Science and Business Media LLC, 2016.
-
Abstract
- Silver nanoparticles (AgNPs) were synthesized using an aqueous Perilla leaf extract and evaluated for anticancer activity. These green -synthesized AgNPs were characterized using UV–Visible absorption spectroscopy, XRD, TEM, and SAED. The synthesized AgNPs were spherical and hexagonal in shape, and the average size of the NPs was ~23 nm. SRB assay investigated the anticancer activity of the AgNPs against human cervical cancer (HeLa) cells. The fluorescence and confocal microscopy studies were confirmed the DNA damage and apoptosis following nanoparticle treatment. Furthermore, the intracellular ROS was also increased after treatment. Taking all these data together, it is suggested that AgNPs may be a potential agent for the inhibition of cervical tumor cells.
- Subjects :
- biology
Stereochemistry
Chemistry
Nanochemistry
Nanoparticle
Biological activity
02 engineering and technology
General Chemistry
010402 general chemistry
021001 nanoscience & nanotechnology
Condensed Matter Physics
Perilla
biology.organism_classification
01 natural sciences
Biochemistry
Fluorescence
Silver nanoparticle
0104 chemical sciences
law.invention
HeLa
Confocal microscopy
law
General Materials Science
0210 nano-technology
Nuclear chemistry
Subjects
Details
- ISSN :
- 15728862 and 10407278
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- Journal of Cluster Science
- Accession number :
- edsair.doi...........156c5570a74e7632c93d0d0e90c58cb3