Back to Search
Start Over
The First Total Synthesis of Pectinolide F
- Source :
- Synthesis. 46:1757-1764
- Publication Year :
- 2014
- Publisher :
- Georg Thieme Verlag KG, 2014.
-
Abstract
- The first total synthesis of the natural saturated α-pyrone pectinolide F has been accomplished from inexpensive, commercially available ( S )-ethyl lactate and but-3-yn-1-ol. The salient features of the synthesis are 2,2,6,6-tetramethylpiperidin-1-oxyl (TEMPO)–[bis(acetoxy)iodo]benzene oxidation, Sharpless asymmetric dihydroxylation, Grignard reaction, and partial hydrogenation of the triple bond.
Details
- ISSN :
- 1437210X and 00397881
- Volume :
- 46
- Database :
- OpenAIRE
- Journal :
- Synthesis
- Accession number :
- edsair.doi...........151a6e23cac3669feff56ba720a9bc45