ChemInform Abstract: Biotransformation in Organic Synthesis: Applications of Yeast Reduction in the Synthesis of 3,5-Dihydroxy Esters of High Optical Purity

All four stereoisomers of methyl 6-(p-chlorophenylthio)-3,5-dihydroxyhexanoate have been synthesised by a route in which the key introduction of chirality was effected by an appropriate yeast reduction.