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Assessment of Blood Brain Barrier Leakage with Gadolinium-Enhanced MRI
- Source :
- Preclinical MRI ISBN: 9781493975303
- Publication Year :
- 2018
- Publisher :
- Springer New York, 2018.
-
Abstract
- The integrity of the blood-brain barrier (BBB) can be noninvasively monitored by magnetic resonance imaging (MRI). Conventional MR contrast agents (CAs) containing gadolinium are used in association with MRI in routine clinical practice to detect and quantify BBB leakage. Under normal circumstances CAs do not cross the intact BBB. However due to their small size they extravasate from the blood into the brain tissue even when the BBB is partially compromised. Here we describe an MR method based on T1-weighted images taken prior to and after CA injection. This MR method is useful for investigating BBB permeability in in vivo mouse models and can be easily applied in a number of experimental disease conditions including neuroinflammation disorders, or to assess (un)wanted drug effects.
- Subjects :
- 0301 basic medicine
medicine.diagnostic_test
business.industry
Gadolinium
chemistry.chemical_element
Magnetic resonance imaging
Mr contrast
Brain tissue
Blood–brain barrier
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
medicine.anatomical_structure
chemistry
In vivo
cardiovascular system
medicine
business
Bbb permeability
030217 neurology & neurosurgery
Neuroinflammation
Biomedical engineering
Subjects
Details
- ISBN :
- 978-1-4939-7530-3
- ISBNs :
- 9781493975303
- Database :
- OpenAIRE
- Journal :
- Preclinical MRI ISBN: 9781493975303
- Accession number :
- edsair.doi...........14decd0c0eaa1182bba387beee9bed3c