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Presence of an Early Lineage Stem Cell Phenotype in Meningioma-Initiating Cells
- Source :
- Stem Cells and Cancer Stem Cells, Volume 10 ISBN: 9789400762619
- Publication Year :
- 2013
- Publisher :
- Springer Netherlands, 2013.
-
Abstract
- Meningiomas are a common form of adult brain tumors. Although most meningiomas are benign tumors that are associated with favorable outcomes, a small group of patients develop more aggressive manifestations which currently are more difficult to treat. It has increasingly been recognized that tumor stem-like cells play critical roles in tumor recurrence, angiogenesis, and invasion in malignant brain tumors. Several recent studies identified the stem-like features of sphere-forming cells in human meningiomas. These meningioma sphere cells expressed various progenitor cell biomarkers and can undergo differentiation if appropriate stimuli are applied. Moreover, these meningioma stem-like cells are more resistant to irradiation treatment, and tumorigenic in in vivo xenograft models. These new findings could lead to a better understanding of the development and etiology of meningioma formation and suggest that meningioma stem-like cells may serve as a novel target in therapeutically resistant meningiomas.
Details
- ISBN :
- 978-94-007-6261-9
- ISBNs :
- 9789400762619
- Database :
- OpenAIRE
- Journal :
- Stem Cells and Cancer Stem Cells, Volume 10 ISBN: 9789400762619
- Accession number :
- edsair.doi...........14c4bbaad7e9b199e19bcd57dad360c5