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Defining an 'ideal' continuous dose-volume constraint curve using literature recommended individual dose-volume thresholds for reducing rectal toxicity from external beam prostate radiation therapy
- Source :
- Journal of Radiation Oncology. 6:405-411
- Publication Year :
- 2017
- Publisher :
- Springer Science and Business Media LLC, 2017.
-
Abstract
- We postulated that a contiguous rectal dose-volume threshold curve obtained via a best mathematical fit of the toughest literature recommended dose-volume thresholds could be deemed as “safe” related to the risk of rectal toxicity. The practicality of restricting rectal doses to such ideal volume thresholds in clinical practice was tested by comparing data collected from a pool of prostate patients treated with external beam radiation therapy (EBRT) in our institution. Available rectal dose-volume constraint recommendation in prostate EBRT was collected. At each dose level, the toughest recommended volume limit was identified and an ideal dose-volume threshold curve was generated using a best mathematical fit. Rectal dose-volume data on 105 prostate patients treated to 75.6 Gy dose with intensity modulated radiation therapy (IMRT) in our institution were retrospectively reviewed. The “ideal” rectal dose-volume threshold curve is defined by V 75 ≤ 7%, V 70 ≤ 11%, V 65 ≤ 15%, V 60 ≤ 20%, V 50 ≤ 30%, V 40 ≤ 43%, and V 30 ≤ 60%. At doses larger or equal to 65 Gy, our patient averaged dose-volume histograms (DVHs) for all groups converged with the ideal curve. At intermediate and low doses (less than 60 Gy), higher volumes of rectum were irradiated than described by the hypothetical curve, with pelvic group receiving more rectal dose than prostate only group respectively. Rectal mean dose correlated strongly with V 40 values (R 2 = 0.84). Our “ideal” rectal dose-volume curve generated from literature dose-volume thresholds in the most stringent manner is realistic and achievable at high doses (≥60 Gy) and not realistic at intermediate and low doses (≤50 Gy). Standardizing rectal definition and dose-volume metrics will make published analyses and dose-volume constraint recommendations easier to follow.
- Subjects :
- medicine.medical_specialty
Ideal (set theory)
business.industry
medicine.medical_treatment
Rectal toxicity
Rectum
Intensity-modulated radiation therapy
030218 nuclear medicine & medical imaging
Surgery
Radiation therapy
03 medical and health sciences
0302 clinical medicine
medicine.anatomical_structure
Volume (thermodynamics)
Prostate
030220 oncology & carcinogenesis
medicine
Individual dose
Nuclear medicine
business
Subjects
Details
- ISSN :
- 19487908 and 19487894
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Journal of Radiation Oncology
- Accession number :
- edsair.doi...........146ec5ec60d15820e2029da89d57e69a