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Cryo-EM structures tell a tale of two telomerases

Authors :
Nicholas M. Forino
Jendrik Hentschel
Michael D. Stone
Source :
Nature Structural & Molecular Biology. 28:457-459
Publication Year :
2021
Publisher :
Springer Science and Business Media LLC, 2021.

Abstract

New atomic-resolution structures provide detailed insights into the molecular mechanism of telomerase, ushering in a new era of rational drug design to target telomerase in human genetic disorders and cancer.

Subjects

Subjects :
0303 health sciences
Telomerase
Cancer
Drug design
Computational biology
Biology
medicine.disease
03 medical and health sciences
0302 clinical medicine
Structural Biology
otorhinolaryngologic diseases
medicine
Molecular mechanism
Molecular Biology
030217 neurology & neurosurgery
030304 developmental biology

Details

ISSN :
15459985 and 15459993
Volume :
28
Database :
OpenAIRE
Journal :
Nature Structural & Molecular Biology
Accession number :
edsair.doi...........14575d04706990972355cba47ace91df
Full Text :
https://doi.org/10.1038/s41594-021-00611-8
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