Ultrasound Assisted Synthesis of Coumarin Thioglycopyranoside Derivatives

The methyl coumarins reacted with N-bromo-succinimide gave compounds (a∼c) which on further reacted with various peracetyl sulfhydryl glycose (1∼3) afforded a series of novel coumarin thioglycopyranoside compounds (1a∼1c, 2a∼2c, 3a∼3c). And when used ultrasonic irradiation, this method offered several advantages such as good yields and short reaction time than the silent reaction. All the new compounds were characterized on the basis of the IR, 1 H NMR, 13 C NMR and elemental analysis.