Feasibility of Augmented Reality Glasses for Real-Time, 3-Dimensional (3D) Intraoperative Guidance

METHODS: Pilot study including 7 subjects undergoing thyroidectomy for papillary thyroid cancer (PTC) diagnosed by fine-needle-aspiration biopsy between August 2012-June 2013. Immediately after removal of the thyroid gland, measurements using light reflectance spectroscopy (LRS) and auto-fluorescence lifetime measurement (AFLM) were taken from the known cancer lesions and compared to those taken in identical fashion from normal thyroid tissue within the same gland. Sites of measurements were identified by the study pathologist and later vetted against the final pathologic diagnosis to ensure they represented the appropriate tissues. The data were compiled and analyzed using SAS repeated measures mixed model (p < 0.05 significant).