Assessing 3 Bronchopulmonary Dysplasia Definitions: Associations between Room Air Challenge Results and Respiratory Outcomes

Background: The Neonatal Research Network (NRN) has used 3 definitions for bronchopulmonary dysplasia (BPD): 1) a clinical definition based on supplemental oxygen at 36 weeks postmenstrual age (PMA) (clinBPD), 2) a physiologic definition inclusive of a room air challenge (RAC) at 36 weeks (physBPD), and 3) a pragmatic definition based on any respiratory support at 36 weeks (pragBPD). PragBPD has been shown to be strongly correlated …