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Pharmacokinetics of acetylsalicylic acid and salicylic acid from slow-release formulations of aspirin in healthy Japanese volunteers
- Source :
- Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics. 16:589-596
- Publication Year :
- 1985
- Publisher :
- Japanese Society of Clinical Pharmacology and Therapeutics, 1985.
-
Abstract
- Acetylsalicylic acid (ASA) and salicylic acid (SA) concentrations in plasma were determined by high-pressure liquid chromatography in 14 healthy male Japanese volunteers after single oral administrations of two different aspirin formulations, enteric-coated granules (Minimax®) and a slow-release tablet (Verin®). Seven subjects received 650 mg and the other seven subjects received 1300 mg of each formulation in a randomly assigned cross-over study. Mean peak SA concentrations in the plasma were significantly higher with the enteric-coated granules than with the slow-release tablets (P
Details
- ISSN :
- 18828272 and 03881601
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics
- Accession number :
- edsair.doi...........13321b075c7ce0b1e3cbfe6d87fd6000