Determination of Organoiodine Antimicrobial Ingredients in Commercially Available Anti microbial/Deodorant Agents

In order to grasp the actual conditions of use of three kinds of organoiodine compounds, 3-iodo-2propynylbutylcarbamate (IPBC), 1-bromo-3-ethoxycarbonyloxy-1,2-diiodo-1-propene (BECDIP), and 4-chlorophenyl3-iodopropargylformal (CPIP), which are used as household antimicrobial/antifungal agents and wood preservatives, an analytical method using a gas chromatograph equipped with a flame ionization detector (FID-GC) and gas chromatography mass spectrometry (GC/MS) was employed. The calibration curve (peak area) by FID-GC showed good linearity in the range from 20 µg/ml to 100 µg/ml (correlation coefficient R = 0.99 or more). A purification method using a liquid‐liquid partition by n-hexane/water and the cartridge column (florisil or alumina) was established, and the addition recovery exceeded 90% by this method. By employing this method, the analysis was carried out for 18 commercially available samples. As a result, IPBC was detected from 2 samples of aerosol type fungicides, BECDIP from 4 samples of wood preservatives, and CPIP from one sample of an aerosol type antifungal/ insecticidal paint.