The modeling of the OSAHS animal model with rats and airflow characteristics simulation of the upper airway

Objective To study the modeling method of animal model of upper stenosis-airway of rats and air flow characteristic. Methods Totally 30 3-month old rats were randomly divided into a control group and a model group. Sodium Hyaluronte 0.1ml was injected into mucosa of the soft palate and the uvula of each rat from the model group in the anesthetic state. After 3-month feeding under the same conditions, the two rat groups were carried out CT Scanning and respiratory experimental examinations, respectively. The Computational Fluid Dynamic Method was then employed to simulate the airflow in upper airway. The flow characteristics are compared between a control rat and a model rat. The minimum cross sectional area of pharyngeal of the model group rats was reduced remarkably than that of the control group, which implies that the airway of the model rats is significantly narrower than that of the control rats with a P-value P