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The antioxidant status, apoptosis, intercellular integrity and immune function of grass carp (Ctenopharyngodon idella) head kidney and spleen fed different levels of pyridoxine
- Source :
- Aquaculture Nutrition. 26:613-630
- Publication Year :
- 2019
- Publisher :
- Hindawi Limited, 2019.
-
Abstract
- This study was carried out to investigate the effects of dietary pyridoxine (PN) on the antioxidant status, apoptosis, intercellular integrity and immune function of head kidney and spleen in young grass carp (Ctenopharyngodon idella). Results showed that compared with the optimal PN level, (a) PN deficiency decreased antioxidant enzyme activities and down‐regulated the mRNA levels of antioxidant enzymes, NF‐E2‐related factor 2 (Nrf2), myeloid cell leukaemia‐1 (Mcl‐1) and tight junction proteins, whereas it increased the contents of reactive oxygen species (ROS), malondialdehyde (MDA) and protein carbonyl (PC), and up‐regulated the mRNA levels of cysteinyl aspartic acid‐protease (caspase), Fas ligand (FasL), p38 mitogen‐activated protein kinase (p38MAPK) and myosin light chain kinase (MLCK) in the head kidney and spleen of fish (p
- Subjects :
- 0303 health sciences
biology
04 agricultural and veterinary sciences
Aquatic Science
Pyridoxine
biology.organism_classification
Malondialdehyde
Molecular biology
Fas ligand
Grass carp
03 medical and health sciences
IκBα
chemistry.chemical_compound
chemistry
Apoptosis
040102 fisheries
medicine
0401 agriculture, forestry, and fisheries
Lysozyme
Protein kinase A
030304 developmental biology
medicine.drug
Subjects
Details
- ISSN :
- 13652095 and 13535773
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Aquaculture Nutrition
- Accession number :
- edsair.doi...........12d415f2957903f9c98247018fac24da