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Chemical composition, antimicrobial and antimycobacterial activities of Aristolochia triangularis Cham. from Brazil
- Source :
- Industrial Crops and Products. 121:461-467
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Three diterpenes (1, 4, 5), four lignans (2, 6, 7a, 7b), one sequiterpene (3) and one alkaloid (8) were isolated from an acidic ether fraction of Aristolochia triangularis Cham. native from Brazil. The compounds were identified as: ent-Kaur-16-en-19-al (1), zuonin B (2), nerolidol (3), (−)-Kaur-16-en-19-oic acid (4), ent-Kauran-16β,17-diol (5), dihydrocubebin (6), a mixture of α and β-cubebin (7a + 7b) and aristolactam BII (8). The methanol extract, fractions and the isolated substances were evaluated to check their antimicrobial/antimycobacterial activity against bacteria (14 strains), fungi (9 strains) and mycobacteria (3 strains). Shigella sonnei was highly susceptible to (−)-Kaur-16-en-19-oic acid (4), which showed a potency similar to the antibacterial substance chloramphenicol (MICs at
- Subjects :
- biology
Traditional medicine
010405 organic chemistry
Chemistry
medicine.drug_class
Chloramphenicol
Alkaloid
biology.organism_classification
Antimicrobial
Antimycobacterial
01 natural sciences
Terpenoid
0104 chemical sciences
010404 medicinal & biomolecular chemistry
chemistry.chemical_compound
medicine
Shigella sonnei
Agronomy and Crop Science
Bacteria
medicine.drug
Nerolidol
Subjects
Details
- ISSN :
- 09266690
- Volume :
- 121
- Database :
- OpenAIRE
- Journal :
- Industrial Crops and Products
- Accession number :
- edsair.doi...........12c0ef45d9cdc97cd65b61f9e8508320
- Full Text :
- https://doi.org/10.1016/j.indcrop.2018.05.052