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Chemical composition, antimicrobial and antimycobacterial activities of Aristolochia triangularis Cham. from Brazil

Authors :
Marli Matiko Anraku de Campos
Alessandra O. Pereira
Fallon dos Santos Siqueira
Janaína M. de Ávila
Ionara I. Dalcol
Ademir F. Morel
Gabrielle do Carmo
Davi F. Back
Source :
Industrial Crops and Products. 121:461-467
Publication Year :
2018
Publisher :
Elsevier BV, 2018.

Abstract

Three diterpenes (1, 4, 5), four lignans (2, 6, 7a, 7b), one sequiterpene (3) and one alkaloid (8) were isolated from an acidic ether fraction of Aristolochia triangularis Cham. native from Brazil. The compounds were identified as: ent-Kaur-16-en-19-al (1), zuonin B (2), nerolidol (3), (−)-Kaur-16-en-19-oic acid (4), ent-Kauran-16β,17-diol (5), dihydrocubebin (6), a mixture of α and β-cubebin (7a + 7b) and aristolactam BII (8). The methanol extract, fractions and the isolated substances were evaluated to check their antimicrobial/antimycobacterial activity against bacteria (14 strains), fungi (9 strains) and mycobacteria (3 strains). Shigella sonnei was highly susceptible to (−)-Kaur-16-en-19-oic acid (4), which showed a potency similar to the antibacterial substance chloramphenicol (MICs at

Details

ISSN :
09266690
Volume :
121
Database :
OpenAIRE
Journal :
Industrial Crops and Products
Accession number :
edsair.doi...........12c0ef45d9cdc97cd65b61f9e8508320
Full Text :
https://doi.org/10.1016/j.indcrop.2018.05.052