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An organocatalytic route to the synthesis of lactone moiety of compactin and mevinolin
- Source :
- Tetrahedron Letters. 51:5838-5839
- Publication Year :
- 2010
- Publisher :
- Elsevier BV, 2010.
-
Abstract
- An efficient synthesis of lactone moiety of compactin has been achieved. The stereogenic centers were generated by means of iterative proline-catalyzed sequential α-aminoxylation and Horner–Wadsworth–Emmons (HWE) olefination of aldehydes.
Details
- ISSN :
- 00404039
- Volume :
- 51
- Database :
- OpenAIRE
- Journal :
- Tetrahedron Letters
- Accession number :
- edsair.doi...........129e2955087225c16d26cef9ad9add3d
- Full Text :
- https://doi.org/10.1016/j.tetlet.2010.08.093