Synthesis and Antiviral Activity of Some Novel Substituted Phenothiazines

Hydroquinone on reaction with amido alcohols 1 in the presence of conc. H 2 SO 4 gives 2-arylamido/imidoalkyl-1,4-dihydroxybenzenes 2 which undergo cyclization with aromatic primary amine and sulphur in the presence of iodine to yield 2-aryl-amido/imidoalkyl-10H-phenothiazin-3-ols 3. Compounds 3 are further substituted to 2-arylamido/imidoalkyl-10-[(4-methoxy-phenyl/phenyl) phenylamino-methyl]-10H-phenothiazin-3-ols 4. Compounds 4 have been screened for their antiviral activity against Japanese encephalitis virus (JEV) and Herpes simplex virus type-I (HSV-I).